Treatment Marble Bone Disease

Advertisement in cases of osteopetrosis in adults there are no treatments required.

Treatment marble bone disease.

At present the only established cure for autosomal recessive malignant infantile osteopetrosis is hematopoietic stem cell transplantation hsct for specific cases. However in cases of children affected with osteopetrosis treatment involves treating complications and improving quality of life. Osteopetrosis literally stone bone also known as marble bone disease or albers schönberg disease is an extremely rare inherited disorder whereby the bones harden becoming denser in contrast to more prevalent conditions like osteoporosis in which the bones become less dense and more brittle or osteomalacia in which the bones soften. This treatment resulted in improvement of growth retardation.

In pediatric childhood osteopetrosis surgery is sometimes needed because of fractures. Bone marrow transplant and splenectomy may be useful in some patients. A recently published article6 reported on the follow up of seven patients with marble bone disease who had received alkaline therapy. Bisphosphonates the medications also used to strengthen bones weakened by osteoporosis are the mainstay of treatment.

Treatment strategies include correcting anemia thrombocytopenia and treating infections. Optimal transplants require donor marrow from a sibling. This allows the restoration of bone resorption by donor derived osteoclasts. For patients who have complications surgery may be necessary.

Osteopetrosis can cause bones to dissolv. Bone marrow transplant is the only complete cure available for malignant marble bone disease. What are treatments for osteopetrosis or marble bone disease. Complications of paget s disease of bone can include broken bones hearing loss and pinched nerves in your spine.

Bone marrow transplant has many risks but if it is successful it saves the life of a child who would otherwise die from complications of the disorder.